IPO11

Across TCGA patient cohorts, IPO11 mutation is significantly associated with the RNA expression of many other genes, with 4,087 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO11-associated genes across cancer lineages are ADPRS, GRHPR, and CYSTM1. Each is linked with IPO11 in more than 2 cancer types. Because this analysis shows association rather than direction, both IPO11-to-partner and partner-to-IPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADPRS grouped by IPO11-low versus IPO11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO11→partner) and Y-score (partner→IPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADPRS →	+0.324	+3.959	.002	<.001	3	3
UCEC	GRHPR →	+0.324	+2.955	.005	<.001	3	3
SKCM	CYSTM1 →	+0.695	+2.745	.001	.003	3	3
UCEC	SAA4 →	-0.554	-2.058	.008	<.001	3	2
UCEC	SRFBP1 →	+0.536	+2.389	.001	<.001	3	2
UCEC	CFDP1 →	+0.392	+2.742	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,087 associations by consensus.

ADPRS by IPO11 expression — UCEC

Explore this box plot interactively →