IPO11

Across TCGA patient cohorts, IPO11 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO11-associated genes across cancer lineages are EGFR_pY1068, FASN, and Notch1. Each is linked with IPO11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO11-to-partner and partner-to-IPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IPO11-low versus IPO11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO11→partner) and Y-score (partner→IPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.249	-2.321	.004	.005	3	2
UCEC	FASN →	+0.398	+2.415	.003	.003	3	2
UCEC	Notch1 →	+0.171	+2.331	<.001	.003	3	2
UCEC	Shc_pY317 →	-0.154	-2.115	.003	.017	3	2
UCEC	STAT3_pY705 →	-0.316	-1.736	<.001	.007	3	2
UCEC	ASNS →	+0.389	+1.807	.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by IPO11 expression — UCEC

Explore this box plot interactively →