IPO11

Across TCGA cell cohorts, IPO11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,755 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPO11-associated GO terms across cancer lineages are DNA replication initiation, Dihydrofolate metabolic process, and Protein import into nucleus. Each is linked with IPO11 in more than 17 cancer types. Because this analysis shows association rather than direction, both IPO11-to-partner and partner-to-IPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by IPO11-low versus IPO11-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO11→partner) and Y-score (partner→IPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.203	+1.174	<.001	<.001	3	18
LUNG_SCLC	Dihydrofolate metabolic process →	+0.194	+0.656	<.001	<.001	3	17
LIVER	Protein import into nucleus →	+0.075	+0.633	.004	.004	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of rRNA processing →	+0.153	+1.018	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Protein localization to condensed chromosome →	+0.164	+1.033	<.001	<.001	3	17
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.118	+0.889	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

DNA replication initiation by IPO11 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →