IPO11

Across TCGA cell cohorts, IPO11 mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPO11-associated genes across cancer lineages are APOL5, ARGFX, and TBC1D3H. Each is linked with IPO11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO11-to-partner and partner-to-IPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by IPO11-low versus IPO11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO11→partner) and Y-score (partner→IPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	2
OVARY	ARGFX →	+0.049	+5.196	<.001	.005	3	1
OVARY	TBC1D3H →	+0.514	+5.196	<.001	.005	3	1
LARGE_INTESTINE	SRRD →	+0.903	+3.169	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.326	+3.502	<.001	.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.651	+3.502	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

APOL5 by IPO11 expression — BLOOD_Leukemia

Explore this box plot interactively →