IPMK

Across TCGA patient cohorts, IPMK mutation is significantly associated with the RNA expression of many other genes, with 692 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPMK-associated genes across cancer lineages are CDT1, KARS1, and MIR6854. Each is linked with IPMK in more than 1 cancer types. Because this analysis shows association rather than direction, both IPMK-to-partner and partner-to-IPMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDT1 grouped by IPMK-low versus IPMK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPMK→partner) and Y-score (partner→IPMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDT1 →	+0.791	+2.721	.001	.003	3	2
UCEC	KARS1 →	+0.429	+2.831	.002	.001	3	2
BLCA	MIR6854 →	+0.502	+5.251	<.001	.006	3	2
LUAD	RSL24D1P2 →	+0.096	+2.925	.005	.008	3	2
LUAD	RPL30P10 →	+0.082	+3.363	.002	.006	3	2
UCEC	GINS2 →	+0.826	+2.592	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 692 associations by consensus.

CDT1 by IPMK expression — UCEC

Explore this box plot interactively →