IPMK

Across TCGA patient cohorts, IPMK mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPMK-associated genes across cancer lineages are STAT3_pY705, ATM, and MEK1. Each is linked with IPMK in more than 1 cancer types. Because this analysis shows association rather than direction, both IPMK-to-partner and partner-to-IPMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by IPMK-low versus IPMK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPMK→partner) and Y-score (partner→IPMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.501	-3.169	<.001	.018	3	2
UCEC	ATM →	-0.674	-2.459	.002	.020	3	2
UCEC	MEK1 →	+0.611	+3.584	<.001	.002	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.503	-3.321	.020	.010	3	1
UCEC	PCNA →	+0.304	+2.999	.003	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.760	+2.189	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

STAT3_pY705 by IPMK expression — UCEC

Explore this box plot interactively →