IPMK

Across TCGA cell cohorts, IPMK mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPMK-associated genes across cancer lineages are NR2E1, ZNF831, and GJA10. Each is linked with IPMK in more than 1 cancer types. Because this analysis shows association rather than direction, both IPMK-to-partner and partner-to-IPMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NR2E1 grouped by IPMK-low versus IPMK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPMK→partner) and Y-score (partner→IPMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NR2E1 →	+0.199	+3.679	<.001	.005	3	1
LARGE_INTESTINE	ZNF831 →	+0.013	+3.688	<.001	.002	3	1
LARGE_INTESTINE	GJA10 →	+0.058	+3.632	<.001	.003	3	1
LARGE_INTESTINE	UGT2A1 →	+0.040	+4.099	.007	.001	3	1
LARGE_INTESTINE	NPAS4 →	+0.029	+3.766	<.001	.004	3	1
LARGE_INTESTINE	HSF5 →	+0.046	+4.000	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

NR2E1 by IPMK expression — LARGE_INTESTINE

Explore this box plot interactively →