IPCEF1

Across TCGA patient cohorts, IPCEF1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPCEF1-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and eEF2. Each is linked with IPCEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPCEF1-to-partner and partner-to-IPCEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by IPCEF1-low versus IPCEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPCEF1→partner) and Y-score (partner→IPCEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.463	-2.115	<.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.566	+2.341	.020	.019	3	2
UCEC	eEF2 →	+0.416	+2.000	.004	.030	3	1
UCEC	INPP4B →	-0.378	-3.700	.004	.001	3	1
UCEC	MEK1 →	+0.461	+3.000	.002	.001	3	1
UCEC	mTOR_pS2448 →	-0.153	-3.308	.013	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

STAT3_pY705 by IPCEF1 expression — UCEC

Explore this box plot interactively →