IP6K1

Across TCGA pan-cancer cohorts, IP6K1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IP6K1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IP6K1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IP6K1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where IP6K1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.985	0.900	.001	35	view →
UCEC	OS	Median	II,III,IV	0.620	1.000	.011	30	view →
LUAD	DFS	Median	III,IV	0.885	0.595	.017	16	view →
CCRCC	DFS	Median	II,III,IV	0.836	0.577	.010	16	view →
PDAC	DFS	Tertile	III,IV	0.826	0.569	.034	3	view →
LSCC	DFS	Tertile	All	0.859	0.697	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IP6K1–HNSC (DFS)

Open the HNSC breakdown →