IP6K1

Across TCGA patient cohorts, IP6K1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IP6K1-associated genes across cancer lineages are ERK2, mTOR_pS2448, and Notch1. Each is linked with IP6K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IP6K1-to-partner and partner-to-IP6K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by IP6K1-low versus IP6K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K1→partner) and Y-score (partner→IP6K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.166	+2.999	.019	.035	3	2
UCEC	mTOR_pS2448 →	-0.151	-3.571	.005	.002	3	2
UCEC	Notch1 →	+0.181	+3.713	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.161	-1.874	.003	.049	3	2
UCEC	BRD4 →	+0.294	+2.115	.002	.016	3	2
UCEC	4E-BP1 →	+0.296	+2.614	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by IP6K1 expression — UCEC

Explore this box plot interactively →