IP6K1

Across TCGA cell cohorts, IP6K1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,180 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IP6K1-associated GO terms across cancer lineages are Positive regulation of pinocytosis, Establishment of mitotic spindle localization, and Positive regulation of TORC2 signaling. Each is linked with IP6K1 in more than 16 cancer types. Because this analysis shows association rather than direction, both IP6K1-to-partner and partner-to-IP6K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of pinocytosis grouped by IP6K1-low versus IP6K1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K1→partner) and Y-score (partner→IP6K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of pinocytosis →	+0.129	+0.828	.002	<.001	3	17
BLOOD_Myeloma	Establishment of mitotic spindle localization →	+0.093	+0.799	.002	.002	3	16
BLOOD_Myeloma	Positive regulation of TORC2 signaling →	+0.110	+0.882	.005	.005	2	16
OVARY	Establishment of spindle localization →	+0.106	+0.796	<.001	<.001	3	15
STOMACH	Negative regulation of smoothened signaling pathway →	+0.101	+1.015	<.001	<.001	3	15
KIDNEY	Nucleosome disassembly →	+0.179	+1.167	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,180 associations by consensus.

Positive regulation of pinocytosis by IP6K1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →