IP6K1

Across TCGA cell cohorts, IP6K1 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IP6K1-associated genes across cancer lineages are KRAS (G12C) Inhibitor-12, Dactinomycin, and Ispinesib Mesylate. Each is linked with IP6K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IP6K1-to-partner and partner-to-IP6K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRAS (G12C) Inhibitor-12 grouped by IP6K1-low versus IP6K1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IP6K1→partner) and Y-score (partner→IP6K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.550	+2.868	.019	.022	3	1
LARGE_INTESTINE	Dactinomycin →	+0.611	+2.649	.033	.046	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.755	+2.874	.013	.021	3	1
LARGE_INTESTINE	Genentech Cpd 10 →	+0.735	+2.874	.009	.021	3	1
LARGE_INTESTINE	GSK1070916 →	+0.606	+2.655	.043	.044	3	1
LARGE_INTESTINE	SU11274 →	+0.499	+2.874	.010	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

KRAS (G12C) Inhibitor-12 by IP6K1 expression — LARGE_INTESTINE

Explore this box plot interactively →