INTS7

Across TCGA patient cohorts, INTS7 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS7-associated genes across cancer lineages are INPP4B, PCNA, and PDCD4. Each is linked with INTS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS7-to-partner and partner-to-INTS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by INTS7-low versus INTS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS7→partner) and Y-score (partner→INTS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.262	-3.906	.015	<.001	3	2
UCEC	PCNA →	+0.189	+2.169	.009	.003	3	2
UCEC	PDCD4 →	-0.481	-2.115	.002	.016	3	2
UCEC	Src_pY527 →	-0.351	-1.797	.014	.025	3	2
UCEC	TFRC →	+0.427	+2.222	.016	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.491	+2.019	.013	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

INPP4B by INTS7 expression — UCEC

Explore this box plot interactively →