INTS6L

Across TCGA patient cohorts, INTS6L mutation is significantly associated with the RNA expression of many other genes, with 4,675 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS6L-associated genes across cancer lineages are KLF16, CA4, and TARS1. Each is linked with INTS6L in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS6L-to-partner and partner-to-INTS6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF16 grouped by INTS6L-low versus INTS6L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS6L→partner) and Y-score (partner→INTS6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KLF16 →	+0.472	+2.279	.005	.005	3	3
LUAD	CA4 →	-0.846	-2.688	.008	.006	3	3
UCEC	TARS1 →	+0.430	+1.498	<.001	.003	3	3
UCEC	DPP9 →	+0.442	+2.280	<.001	<.001	3	3
SKCM	BTNL9 →	-0.612	-3.687	.003	.001	3	3
UCEC	RNA5SP146 →	+0.168	+1.485	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,675 associations by consensus.

KLF16 by INTS6L expression — SKCM

Explore this box plot interactively →