INTS6L

Across TCGA cell cohorts, INTS6L mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS6L-associated genes across cancer lineages are GCAT, TTC19, and MPL. Each is linked with INTS6L in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS6L-to-partner and partner-to-INTS6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by INTS6L-low versus INTS6L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS6L→partner) and Y-score (partner→INTS6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.067	+3.364	.009	.002	3	1
LARGE_INTESTINE	TTC19 →	+0.711	+3.364	.001	.002	3	1
LARGE_INTESTINE	MPL →	+0.129	+3.184	<.001	.007	3	1
LARGE_INTESTINE	SERAC1 →	+0.657	+3.067	.002	.009	3	1
LARGE_INTESTINE	METTL16 →	+0.553	+3.364	.002	.002	3	1
LARGE_INTESTINE	ZWILCH →	+0.624	+3.169	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

GCAT by INTS6L expression — LARGE_INTESTINE

Explore this box plot interactively →