INTS6L

Across TCGA cell cohorts, INTS6L mutation is significantly associated with the mutation status of many other genes, with 4,107 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS6L-associated genes across cancer lineages are SPINT1, PRMT3, and APBA3. Each is linked with INTS6L in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS6L-to-partner and partner-to-INTS6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINT1 grouped by INTS6L-low versus INTS6L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS6L→partner) and Y-score (partner→INTS6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINT1 →	+4.239	+5.053	.007	.007	1	3
BLOOD_Leukemia	PRMT3 →	+4.560	+4.309	.007	.007	1	3
SKIN	APBA3 →	+5.824	+5.824	.002	.002	1	3
SKIN	CCDC88A →	+5.824	+5.824	.002	.002	1	3
BLOOD_Leukemia	SALL2 →	+2.975	+3.794	.006	.006	1	3
BLOOD_Leukemia	TLN2 →	+2.390	+4.198	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,107 associations by consensus.

SPINT1 by INTS6L expression — SKIN

Explore this box plot interactively →