INTS6

Across TCGA pan-cancer cohorts, INTS6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated INTS6 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated INTS6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where INTS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.792	0.957	.005	17	view →
LSCC	DFS	Tertile	III,IV	0.417	0.969	.010	8	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
GBM	OS	Median	All	0.701	0.826	.023	2	view →
LUAD	DFS	Median	III,IV	0.924	0.589	.026	2	view →
CCRCC	DFS	Quartile	III,IV	0.779	0.333	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

INTS6–HNSC (OS)

Open the HNSC breakdown →