INTS6

Across TCGA cell cohorts, INTS6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,899 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTS6-associated GO terms across cancer lineages are Protein desumoylation, Negative regulation of hematopoietic stem cell differentiation, and RNA surveillance. Each is linked with INTS6 in more than 14 cancer types. Because this analysis shows association rather than direction, both INTS6-to-partner and partner-to-INTS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein desumoylation grouped by INTS6-low versus INTS6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS6→partner) and Y-score (partner→INTS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein desumoylation →	+0.124	+0.751	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.133	+0.638	<.001	<.001	3	14
SOFT_TISSUE	RNA surveillance →	+0.076	+0.818	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Positive regulation of mRNA metabolic process →	+0.076	+0.776	<.001	<.001	3	13
SOFT_TISSUE	Transcription elongation by RNA polymerase II →	+0.092	+0.796	<.001	<.001	3	13
LUNG_SCLC	Ribosomal protein import into nucleus →	+0.075	+0.757	.003	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,899 associations by consensus.

Protein desumoylation by INTS6 expression — LUNG_SCLC

Explore this box plot interactively →