Across TCGA patient cohorts, INTS5 mutation is significantly associated with the RNA expression of many other genes, with 2,828 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS5-associated genes across cancer lineages are GLOD4, HEXIM2, and ATOH8. Each is linked with INTS5 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS5-to-partner and partner-to-INTS5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS5→partner) and Y-score (partner→INTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GLOD4 →	+0.426	+3.352	.004	.005	3	3
UCEC	HEXIM2 →	+0.378	+1.893	<.001	<.001	3	3
UCEC	ATOH8 →	-0.629	-2.169	.001	<.001	3	3
UCEC	ATPAF2 →	+0.385	+2.180	<.001	<.001	3	3
UCEC	BNIP3 →	+0.614	+2.343	.002	.003	3	3
UCEC	RIMKLA →	+0.491	+1.925	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,828 associations by consensus.

Exploration

INTS5 survival (RNA) · tumor vs normal (RNA) · all INTS5 data types