Across TCGA cell cohorts, INTS5 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS5-associated genes across cancer lineages are FHL5, INSM2, and F11. Each is linked with INTS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS5-to-partner and partner-to-INTS5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS5→partner) and Y-score (partner→INTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FHL5 →	+0.075	+4.312	<.001	.001	3	2
LARGE_INTESTINE	INSM2 →	+0.349	+3.428	.007	.008	3	2
LARGE_INTESTINE	F11 →	+0.037	+2.560	<.001	.008	3	2
BLOOD_Myeloma	SCYGR2 →	+0.140	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUSC	GPX6 →	+0.023	+4.643	<.001	.008	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+4.844	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

INTS5 survival (RNA) · tumor vs normal (RNA) · all INTS5 data types