INTS4P2

Across TCGA patient cohorts, INTS4P2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS4P2-associated genes across cancer lineages are eEF2, FOXO3a_pS318_S321, and Ku80. Each is linked with INTS4P2 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS4P2-to-partner and partner-to-INTS4P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by INTS4P2-low versus INTS4P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS4P2→partner) and Y-score (partner→INTS4P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.382	+3.321	.041	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.163	-3.321	.012	.010	3	1
UCEC	Ku80 →	+0.257	+3.335	.037	.005	3	1
UCEC	mTOR_pS2448 →	-0.191	-2.980	.014	.036	3	1
UCEC	p70-S6K_pT389 →	-0.244	-2.999	.014	.035	3	1
UCEC	PDCD4 →	-0.678	-2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by INTS4P2 expression — UCEC

Explore this box plot interactively →