INTS4P1

Across TCGA patient cohorts, INTS4P1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS4P1-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and Ku80. Each is linked with INTS4P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS4P1-to-partner and partner-to-INTS4P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by INTS4P1-low versus INTS4P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS4P1→partner) and Y-score (partner→INTS4P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.285	+3.321	.036	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-2.990	.031	.036	3	1
UCEC	Ku80 →	+0.284	+2.183	.021	.035	3	1
UCEC	Notch1 →	+0.204	+2.820	.005	.035	3	1
UCEC	p62 Lck ligand →	+0.639	+3.009	<.001	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.860	+3.321	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by INTS4P1 expression — UCEC

Explore this box plot interactively →