INTS4

Across TCGA pan-cancer cohorts, INTS4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INTS4 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher INTS4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and LUSC are the cancer types where INTS4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.925	0.436	.019	16	view →
LUSC	OS	Median	II,III,IV	0.080	0.743	<.001	12	view →
SARC	OS	Median	All	0.164	0.827	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

INTS4–ACC (DFS)

Open the ACC breakdown →