INTS4

Across TCGA patient cohorts, INTS4 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS4-associated genes across cancer lineages are GAPDH, NF-kB-p65_pS536, and PCNA. Each is linked with INTS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS4-to-partner and partner-to-INTS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by INTS4-low versus INTS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS4→partner) and Y-score (partner→INTS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.409	+2.000	.020	.029	3	3
COAD	NF-kB-p65_pS536 →	-0.911	-2.991	<.001	.036	2	3
COAD	PCNA →	+0.385	+3.008	.002	.019	3	2
UCEC	PDCD4 →	-0.642	-2.906	<.001	.001	3	2
COAD	RAD51 →	+0.249	+3.008	.002	.019	3	2
COAD	XBP1 →	+0.203	+3.008	.040	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

GAPDH by INTS4 expression — UCEC

Explore this box plot interactively →