INTS4

Across TCGA cell cohorts, INTS4 mutation is significantly associated with the RNA expression of many other genes, with 192 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS4-associated genes across cancer lineages are GCAT, RBFA, and ZNF330. Each is linked with INTS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS4-to-partner and partner-to-INTS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by INTS4-low versus INTS4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS4→partner) and Y-score (partner→INTS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.436	+3.212	<.001	.006	3	1
LARGE_INTESTINE	RBFA →	+0.757	+3.212	.003	.006	3	1
LARGE_INTESTINE	ZNF330 →	+0.516	+3.212	.004	.006	3	1
LARGE_INTESTINE	PPP2R5D →	+0.646	+3.212	.004	.006	3	1
LARGE_INTESTINE	PCCB →	+0.745	+3.295	<.001	.003	3	1
LARGE_INTESTINE	CYB561D2 →	+0.477	+3.299	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 192 associations by consensus.

GCAT by INTS4 expression — LARGE_INTESTINE

Explore this box plot interactively →