INTS3

Across TCGA pan-cancer cohorts, INTS3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INTS3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated INTS3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where INTS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.763	0.926	<.001	60	view →
PDAC	DFS	Median	II,III,IV	0.590	0.862	.002	28	view →
CCRCC	OS	Median	All	0.888	1.000	.003	22	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.834	.035	8	view →
LSCC	OS	Quartile	III,IV	0.628	0.901	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INTS3–HNSC (OS)

Open the HNSC breakdown →