INTS3

Across TCGA patient cohorts, INTS3 mutation is significantly associated with the RNA expression of many other genes, with 2,346 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS3-associated genes across cancer lineages are MSANTD3, LMNA, and HMGB1P26. Each is linked with INTS3 in more than 3 cancer types. Because this analysis shows association rather than direction, both INTS3-to-partner and partner-to-INTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSANTD3 grouped by INTS3-low versus INTS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS3→partner) and Y-score (partner→INTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSANTD3 →	+0.330	+1.525	.002	<.001	3	4
SKCM	LMNA →	+0.518	+3.613	.005	.001	3	4
UCEC	HMGB1P26 →	+0.125	+1.385	<.001	.001	3	3
BRCA	GNG5P5 →	+0.065	+4.054	.001	.009	3	3
SKCM	MFSD12 →	+0.832	+2.594	.003	.006	3	3
UCEC	MON1A →	+0.320	+2.654	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,346 associations by consensus.

MSANTD3 by INTS3 expression — UCEC

Explore this box plot interactively →