INTS3

Across TCGA patient cohorts, INTS3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS3-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eIF4G. Each is linked with INTS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS3-to-partner and partner-to-INTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by INTS3-low versus INTS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS3→partner) and Y-score (partner→INTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.444	-2.723	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.649	+1.807	<.001	.003	3	3
UCEC	eIF4G →	+0.181	+1.874	.036	.049	3	2
UCEC	GATA6 →	-0.107	-1.099	.013	.020	3	2
UCEC	Notch1 →	+0.145	+1.483	<.001	.003	3	2
UCEC	Caspase-8 →	-0.234	-1.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by INTS3 expression — UCEC

Explore this box plot interactively →