INTS14

Across TCGA pan-cancer cohorts, INTS14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INTS14 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS14 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where INTS14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.548	0.881	.003	28	view →
CCRCC	OS	Median	All	0.890	1.000	.004	22	view →
PDAC	OS	Median	All	0.942	0.806	.009	8	view →
GBM	OS	Quartile	All	0.696	0.934	.041	2	view →
LUAD	DFS	Median	III,IV	0.924	0.590	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INTS14–HNSC (DFS)

Open the HNSC breakdown →