INTS14

Across TCGA patient cohorts, INTS14 mutation is significantly associated with the RNA expression of many other genes, with 1,595 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS14-associated genes across cancer lineages are NPAT, CENPU, and GPATCH11. Each is linked with INTS14 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS14-to-partner and partner-to-INTS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAT grouped by INTS14-low versus INTS14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS14→partner) and Y-score (partner→INTS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPAT →	+0.625	+4.000	<.001	<.001	3	2
UCEC	CENPU →	+1.008	+4.032	<.001	<.001	3	2
UCEC	GPATCH11 →	+0.607	+4.010	<.001	<.001	3	2
UCEC	BUB1B →	+0.832	+3.329	.002	.005	3	2
UCEC	LSM12 →	+0.705	+2.625	<.001	.005	3	2
UCEC	RACGAP1 →	+0.733	+2.233	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,595 associations by consensus.

NPAT by INTS14 expression — UCEC

Explore this box plot interactively →