INTS13

Across TCGA patient cohorts, INTS13 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS13-associated genes across cancer lineages are JNK_pT183_Y185, MEK1_p_S217_S221, and C-Raf. Each is linked with INTS13 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS13-to-partner and partner-to-INTS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by INTS13-low versus INTS13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS13→partner) and Y-score (partner→INTS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.128	-1.752	.042	.014	3	2
BLCA	MEK1_p_S217_S221 →	+0.319	+2.824	.003	.036	3	1
SKCM	C-Raf →	+0.239	+3.169	.001	.019	3	1
UCEC	MSH2 →	-0.289	-2.558	<.001	.010	3	1
UCEC	p27_pT198 →	+0.120	+1.765	.002	.014	3	1
UCEC	PCNA →	+0.223	+2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK_pT183_Y185 by INTS13 expression — UCEC

Explore this box plot interactively →