INTS12

Across TCGA pan-cancer cohorts, INTS12 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INTS12 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS12 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where INTS12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.606	0.891	.001	49	view →
GBM	OS	Tertile	All	0.664	0.439	.005	15	view →
CCRCC	OS	Quartile	All	0.657	1.000	.021	5	view →
PDAC	OS	Median	II,III,IV	0.393	0.564	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

INTS12–HNSC (DFS)

Open the HNSC breakdown →