INTS12

Across TCGA patient cohorts, INTS12 mutation is significantly associated with the RNA expression of many other genes, with 340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS12-associated genes across cancer lineages are RNA5SP367, SNORD116-23, and CCDC15. Each is linked with INTS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS12-to-partner and partner-to-INTS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP367 grouped by INTS12-low versus INTS12-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS12→partner) and Y-score (partner→INTS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP367 →	+0.395	+5.038	<.001	.009	3	2
SKCM	SNORD116-23 →	+0.686	+5.508	<.001	<.001	3	2
UCEC	CCDC15 →	+0.539	+3.475	<.001	.002	3	1
UCEC	AP1S3 →	+0.657	+3.459	.001	.005	3	1
UCEC	GPATCH11 →	+0.474	+2.711	.005	.003	3	1
UCEC	DDAH1 →	+0.893	+3.480	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 340 associations by consensus.

RNA5SP367 by INTS12 expression — BLCA

Explore this box plot interactively →