INTS12

Across TCGA patient cohorts, INTS12 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS12-associated genes across cancer lineages are GATA6, GSK3-a-b, and p38-MAPK. Each is linked with INTS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS12-to-partner and partner-to-INTS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by INTS12-low versus INTS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS12→partner) and Y-score (partner→INTS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.160	-2.314	.038	.035	3	1
UCEC	GSK3-a-b →	-0.175	-2.321	.010	.035	3	1
UCEC	p38-MAPK →	-0.201	-2.321	.014	.035	3	1
UCEC	TSC1 →	-0.258	-2.321	.002	.035	3	1
UCEC	Caspase-8 →	-0.248	-2.973	.049	.035	3	1
UCEC	MEK1 →	+0.459	+3.000	.012	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GATA6 by INTS12 expression — UCEC

Explore this box plot interactively →