INTS11

Across TCGA pan-cancer cohorts, INTS11 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated INTS11 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS11 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where INTS11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.355	0.911	.005	27	view →
PDAC	DFS	Tertile	III,IV	0.620	0.224	.012	9	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

INTS11–HNSC (DFS)

Open the HNSC breakdown →