INTS11

Across TCGA patient cohorts, INTS11 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS11-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and GAPDH. Each is linked with INTS11 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS11-to-partner and partner-to-INTS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by INTS11-low versus INTS11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS11→partner) and Y-score (partner→INTS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.308	+2.467	<.001	.011	3	3
UCEC	A-Raf_pS299 →	-0.165	-2.000	.001	.030	3	2
UCEC	GAPDH →	+0.642	+3.321	.004	.009	3	2
COAD	Lck →	+0.553	+3.000	<.001	.034	3	2
UCEC	ATM →	-0.415	-1.700	.031	.044	3	2
UCEC	4E-BP1 →	+0.375	+3.730	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by INTS11 expression — COAD

Explore this box plot interactively →