INTS11

Across TCGA cell cohorts, INTS11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,115 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INTS11-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Negative regulation of RNA splicing. Each is linked with INTS11 in more than 15 cancer types. Because this analysis shows association rather than direction, both INTS11-to-partner and partner-to-INTS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by INTS11-low versus INTS11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS11→partner) and Y-score (partner→INTS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.156	+0.926	<.001	<.001	3	16
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.161	+0.945	<.001	<.001	3	16
BONE	Negative regulation of RNA splicing →	+0.114	+1.214	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.088	+0.702	<.001	<.001	3	16
BONE	Regulation of DNA repair →	+0.093	+1.073	<.001	<.001	3	16
BONE	Positive regulation of mitophagy →	+0.111	+0.972	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,115 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by INTS11 expression — BONE

Explore this box plot interactively →