INTS10

Across TCGA pan-cancer cohorts, INTS10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INTS10 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS10 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, PDAC, and COAD are the cancer types where INTS10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.860	1.000	.016	26	view →
PDAC	DFS	Tertile	II,III,IV	0.577	0.779	.010	25	view →
COAD	DFS	Median	II,III,IV	1.000	0.897	.038	12	view →
CCRCC	OS	Median	II,III,IV	0.554	1.000	.025	6	view →
LSCC	DFS	Tertile	II,III,IV	0.887	0.556	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INTS10–HNSC (DFS)

Open the HNSC breakdown →