INTS10

Across TCGA patient cohorts, INTS10 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INTS10-associated genes across cancer lineages are FoxM1, Mre11, and p27_pT198. Each is linked with INTS10 in more than 2 cancer types. Because this analysis shows association rather than direction, both INTS10-to-partner and partner-to-INTS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by INTS10-low versus INTS10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS10→partner) and Y-score (partner→INTS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.190	+1.502	.045	.030	3	3
UCEC	Mre11 →	-0.064	-1.502	.042	.030	3	2
UCEC	p27_pT198 →	+0.078	+1.502	.048	.030	3	2
UCEC	Bak →	+0.193	+2.700	.036	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.620	+1.720	.004	.025	3	2
UCEC	Di-Ras3 →	-0.199	-3.687	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FoxM1 by INTS10 expression — UCEC

Explore this box plot interactively →