INTS10

Across TCGA cell cohorts, INTS10 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INTS10-associated genes across cancer lineages are PROKR2, PTCHD3, and MRAP. Each is linked with INTS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both INTS10-to-partner and partner-to-INTS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROKR2 grouped by INTS10-low versus INTS10-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INTS10→partner) and Y-score (partner→INTS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PROKR2 →	+0.546	+5.000	<.001	.005	3	1
KIDNEY	PTCHD3 →	+0.006	+5.000	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	CFHR2 →	+0.069	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	C2orf80 →	+0.056	+4.371	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PROKR2 by INTS10 expression — KIDNEY

Explore this box plot interactively →