INTS1

Across TCGA pan-cancer cohorts, INTS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated INTS1 data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INTS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INTS1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where INTS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.900	1.000	.003	44	view →
CCRCC	DFS	Tertile	III,IV	0.809	1.000	.015	14	view →
LSCC	DFS	Quartile	All	0.839	0.553	.015	8	view →
PDAC	DFS	Quartile	II,III,IV	0.276	0.478	.018	7	view →
GBM	OS	Median	All	0.594	0.457	.035	1	view →
LUAD	DFS	Median	II,III,IV	1.000	0.819	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

INTS1–HNSC (DFS)

Open the HNSC breakdown →