Across TCGA pan-cancer cohorts, INSYN2B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated INSYN2B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher INSYN2B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated INSYN2B expression acts as an unfavorable survival marker.

COAD and UCEC are the cancer types where INSYN2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.328	0.798	.004	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: INSYN2B tumor-vs-normal RNA expression · all INSYN2B data types