Across TCGA pan-cancer cohorts, INSYN1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated INSYN1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher INSYN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated INSYN1 expression acts as an unfavorable survival marker.

READ and LUSC are the cancer types where INSYN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	45	view →
LUSC	OS	Median	II,III,IV	0.265	0.631	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: INSYN1 tumor-vs-normal RNA expression · all INSYN1 data types