INSRR

Across TCGA pan-cancer cohorts, INSRR Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated INSRR data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher INSRR Mutation is associated with better overall survival. In most high-consensus cancer types, elevated INSRR expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, KICH, and OV are the cancer types where INSRR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.964	0.672	.002	16	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
OV	OS	Median	IV	0.007	0.760	<.001	12	view →
UCEC	DFS	Median	All	0.930	0.824	.015	12	view →
UCS	OS	Median	All	0.258	0.694	.008	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

INSRR–SKCM (OS)

Open the SKCM breakdown →