INSRR

Across TCGA pan-cancer cohorts, INSRR mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of INSRR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where INSRR mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types INSRR is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and CCRCC are the cancer types where INSRR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INSRR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.553	<.001	11	view →
COAD	Female	II,III,IV	−0.347	<.001	11	view →
CCRCC	Male	All	−0.193	<.001	10	view →
LSCC	Female	II,III,IV	−0.492	<.001	9	view →
LUAD	Male	III,IV	−0.191	.032	2	view →
PDAC	Male	IV	−0.385	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

INSRR–HNSC

Open the HNSC breakdown →