INSRR

Across TCGA patient cohorts, INSRR mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSRR-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and ASNS. Each is linked with INSRR in more than 3 cancer types. Because this analysis shows association rather than direction, both INSRR-to-partner and partner-to-INSRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by INSRR-low versus INSRR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSRR→partner) and Y-score (partner→INSRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.155	+2.183	.002	.001	3	3
UCEC	p62 Lck ligand →	+0.232	+2.321	.003	<.001	3	3
UCEC	ASNS →	+0.222	+1.078	.012	.006	3	3
UCEC	4E-BP1 →	+0.304	+2.643	<.001	<.001	3	3
LUAD	AMPK_alpha →	-0.126	-3.136	.041	.018	3	2
LUAD	Annexin_VII →	-0.094	-1.890	.035	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

eIF4E by INSRR expression — UCEC

Explore this box plot interactively →