INSRR

Across TCGA cell cohorts, INSRR RNA expression is significantly associated with the go_rna of many other GO terms, with 1,046 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INSRR-associated GO terms across cancer lineages are Regulation of proteasomal protein catabolic process, Negative regulation of syncytium formation by plasma membrane fusion, and Negative regulation of cilium assembly. Each is linked with INSRR in more than 7 cancer types. Because this analysis shows association rather than direction, both INSRR-to-partner and partner-to-INSRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal protein catabolic process grouped by INSRR-low versus INSRR-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSRR→partner) and Y-score (partner→INSRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of proteasomal protein catabolic process →	+0.048	+0.868	.001	.002	3	8
BLOOD_Leukemia	Negative regulation of syncytium formation by plasma membrane fusion →	+0.056	+0.061	<.001	<.001	3	6
SOFT_TISSUE	Negative regulation of cilium assembly →	+0.059	+0.099	<.001	.009	3	5
STOMACH	Positive regulation of intracellular protein transport →	+0.079	+0.041	<.001	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	Cellular response to starvation →	+0.039	+0.015	.001	.007	3	5
PANCREAS	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.067	+0.014	<.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,046 associations by consensus.

Regulation of proteasomal protein catabolic process by INSRR expression — LUNG_SCLC

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