INSRR

Across TCGA cell cohorts, INSRR mutation is significantly associated with the RNA expression of many other genes, with 1,132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSRR-associated genes across cancer lineages are GCH1, TRIM7, and PGGT1B. Each is linked with INSRR in more than 2 cancer types. Because this analysis shows association rather than direction, both INSRR-to-partner and partner-to-INSRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCH1 grouped by INSRR-low versus INSRR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSRR→partner) and Y-score (partner→INSRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCH1 →	+0.510	+3.321	.005	.003	3	3
LARGE_INTESTINE	TRIM7 →	+1.263	+2.158	.003	.004	3	3
LARGE_INTESTINE	PGGT1B →	+0.616	+2.850	.008	<.001	3	3
URINARY_TRACT	PZP →	+0.214	+4.217	.001	.005	3	2
LARGE_INTESTINE	SH3GL2 →	+1.103	+2.252	<.001	.004	3	2
LARGE_INTESTINE	UFSP2 →	+0.651	+3.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,132 associations by consensus.

GCH1 by INSRR expression — LARGE_INTESTINE

Explore this box plot interactively →