INSRR

Across TCGA cell cohorts, INSRR mutation is significantly associated with the mutation status of many other genes, with 6,873 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSRR-associated genes across cancer lineages are AKAP13, EP300, and KMT2A. Each is linked with INSRR in more than 6 cancer types. Because this analysis shows association rather than direction, both INSRR-to-partner and partner-to-INSRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAP13 grouped by INSRR-low versus INSRR-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSRR→partner) and Y-score (partner→INSRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AKAP13 →	+3.201	+3.201	<.001	<.001	1	7
BONE	EP300 →	+4.437	+5.000	.007	.007	1	6
SOFT_TISSUE	KMT2A →	+3.307	+3.777	.005	.005	1	6
UPPER_AERODIGESTIVE_TRACT	ANKRD17 →	+5.193	+4.539	<.001	<.001	1	6
BLOOD_Leukemia	UNC79 →	+2.347	+2.584	.004	.004	1	6
SOFT_TISSUE	TNXB →	+3.722	+4.977	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,873 associations by consensus.

AKAP13 by INSRR expression — CNS

Explore this box plot interactively →