INSR

Across TCGA pan-cancer cohorts, INSR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated INSR data layer compared with 21 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher INSR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated INSR expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where INSR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.942	0.376	<.001	43	view →
CCRCC	DFS	Median	III,IV	0.772	0.363	<.001	24	view →
HNSC	OS	Quartile	IV	0.523	0.850	.018	17	view →
GBM	OS	Quartile	All	0.219	0.552	.011	8	view →
UCEC	DFS	Quartile	All	0.808	1.000	.015	6	view →
LSCC	OS	Median	All	1.000	0.800	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

INSR–PDAC (DFS)

Open the PDAC breakdown →